An increasing number of research studies over recent years have focused on the function of microRNA (miRNA) molecules which\nhave unique characteristics in terms of structure and function.They represent a class of endogenous noncoding single-strand small\nmolecules. An abundance of miRNA clusters has been found in the genomes of various organisms often located in a polycistron.\nThe miR-17-92 family is among the most famous miRNAs and has been identified as an oncogene. The functions of this cluster,\ntogether with the seven individual molecules that it comprises, are most related to cancers, so it would not be surprising that they\nare considered to have involvement in the development of tumors. The miR-17-92 cluster is therefore expected not only to be a\ntumor marker, but also to perform an important role in the early diagnosis of those diseases and possibly also be a target for tumor\nbiotherapy. The miR-17-92 cluster affects the development of disease by regulating many related cellular processes and multiple\ntarget genes. Interestingly, it also has important roles that cannot be ignored in disease of the nervous system and circulation and\nmodulates the growth and development of bone. Therefore, it provides newopportunities for disease prevention, clinical diagnosis,\nprognosis, and targeted therapy. Here we review the role of the miR-17-92 cluster that has received little attention in relation to\nneurological diseases, cardiac diseases, and the development of bone and tumors.
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